A new study re-analyzed a previous research on paroxetine, a drug known for being effective against depression in adolescents. Researchers have found that it was not as affective as we thought, even worse, it may come with serious side effects.
The new analysis found that undisclosed data from a previous study showed that the drug had some serious side effects, such as suicidal behaviours and self-harming tendencies.The drug is branded as Aropax, Seroxat or Paxil. The original study was published in 2001 by the pharmaceutical company GlaxoSmithKline. The study gathered trials from between 1994 and 1998.
Jon Jureidini, professor at the University of Adelaide’s Critical and Ethical Mental Health Research Group, said that the results of the said study were concerning because the drug was in fact not as effective as we may think. In fact, it was no more effective at preventing depression than placebo medication. Jureidini declared that prescribing paroxetine to young patients may put them in unnecessary danger, instead of helping them relieve their depression symptoms. During the study, eleven out of nearly 100 patients that were on paroxetine experienced suicidal or self-harm tendencies.
The study was published in the British Medical Association Journal. It is the first study of a new programme dubbed Restoring Ivisible and Abandoned Trials (RIAT). The studies under this initiative are aiming to uncover misreported trials, more precise, to correct misleading publications. Peter Doshi, editor at The British Media Association Journal, said that the original study should be retracted. The previous study was published in the Journal of American Academy of Child and Adolescent Psychiatry.
Doshi said that the original study’s paper was not even written by any of its authors, instead the drug company that funded the study preferred to hire and outside medical writer to do the job for them.
The company has a long history with frauds apparently. They are called GlaxoSmithKline now, and are known for being fined a record $3 billion by the Food and Drug Administration back in 2012.
Jureidini said that his team of researchers learned a lot from re-analyzing the original study and are now better prepared to expose more misleading studies. He adds that research authorities should make all the data and protocols more accessible, explaining that it was extremely difficult to get his hands on the data from GlaxoSmithKline.
Billions of paroxetine pills were prescribed during the 1980s and 1980s. At that time, the drug was widely regarded as a highly effective antidepressant pill which had considerably less side effects than earlier medication of this kind.
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