Every up has a downside too and anti-depressants are no exception to the rule. A new study reveals that a certain class of anti-depressants, designed to curb menopausal symptoms, boost bone fracture risk. And we’re not talking about an insignificant exposure to the affection, as research shows that women are exposed to a 76% risk to weaken their bone structure after following an extensive treatment against depression.
The considerable risk is highly associated with selective serotonin reuptake inhibitors or SSRIs and exposure to the related affection lasts for many years after ceasing the pill intake. SSRIs are known to increase fracture risk among middle aged women without psychiatric disorders. Treatment length affects the development of the affection, as shorter duration is known to decrease the risk.
Researchers have reached the surprising conclusion after leading a study based on the analysis of 137.031 women with no mental health issues, aged between 40 and 64 and exposed to treatment with SSRI’s between 1998 and 2001.
The fracture rate is known to be 76% higher among those prescribed SSRIs and analyzed one year after proceeding with the treatment. Two years after treatment, women are exposed to a 73% higher risk, while five years after treatment are associated with a 67% higher risk to develop vulnerability in bone structure.
The risks are extremely surprising, the more so SSRIs are the third most frequently prescribed class of drugs in the US only. The medication is commonly suggested for non-psychiatric disorders and is addressed to slight mood swings and depression bursts during menopause.
The range of drugs includes hydrobromide, fluoxetine hydrochloride, escitalopram oxalate, paroxetine hydrochloride, fluvoxamine maleate and sertraline hydrochloride. All these substances are used in menopausal disorder treatments and come with the above mentioned risks.
Doctors are more inclined to prescribe anti-depressants rather than hormone replacement therapy, as the second one is known to increase the risk of heart problems. On the other hand, anti-depressants boost risk of bone fracture in women to a very high degree so the balance slowly starts to swing back in favor of hormone replacement treatments.
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