A team of scientists from the Scripps Research Institute has developed a new drug that could be used as a treatment for osteoporosis and other bone conditions.
The researchers have managed to develop the new drug by investigating a protein known as PPARG and how it can affect the stem cells of the bone marrow.
Patrick Griffin, one of the researchers at the Translational Research Institute at Scripps Research Institute, explained that the new findings suggest for the first time the effects of a drug that can target the protein PPARG.
Griffin added that researchers have been trying for some time to treat type 2 diabetes with insulin sensitizers.
The team of scientists has designed a compound called SR2595 and used it to repress the PPARG protein.
According to their findings, a reduce amount of PPARG protein in lab mice was shown to encourage bone growth.
This means that it could also be used as a new treatment for osteoporosis and other bone-related medical conditions.
Scientists found that the new drug proved successful in treating various illnesses in mice models.
Also, the experts tried the new drug on human mesenchymal stem cells and with positive results.
According to their study, after using the new drug there was an increase in osteoblast formation, which is type of cell that helps bone tissue to form.
Griffin said his team has already proved that SR2595 has positive effects on lab mice.
The next step of the study is to analyze the effects of the new drug on other conditions such as bone loss, diabetes, obesity and aging.
David P. Marciano, one of the lead authors of the study, explained that due to the fact PPARG is very similar to other proteins that play an important role in this disease, the researchers can apply the same structural insights in order to develop new compounds that could be used for treating numerous health problems.
According to recent statistics, osteoporosis is responsible for almost 9 million bone fractures annually. This means that every 3 seconds, an individual suffers from an osteoporotic fracture.
The findings were published in the journal Nature Communications.
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