Tuberculosis is one acute disease which can easily put one’s life in danger. It is caused by bacteria which attack one’s respiratory system, and can sometimes turn resistant to drugs. In a new scientific breakthrough, a team of researchers managed to find a substance which can combat the effects of these bacteria.
Tuberculosis can easily get resistant to antibiotics
The miraculous substance is called beta lactone EZ120, and it was found to attack the mycomembrane which covers the bacteria. As mentioned above, the bacteria can develop a potential resistance to antibiotics, which can easily turn tuberculosis into a deadly disease. The resistance is caused precisely by this membrane that gets attacked by the substances.
Researchers discovered that mixing EZ120 with common antibiotics used to treat tuberculosis can really make a great combination. The substance has quite a big effectiveness rate even when used in low concentrations. When adding the antibiotics, the effect is instantly improved. Stephan Sieber, one of the researchers from the Technical University of Munich, Germany, explained how this worked.
“Vancomycin, a common antibiotic, and EZ120 work together very well. When used together, the dose can be reduced over 100-fold.”
The substance can break down the bacteria’s protective membrane
This mycomembrane of the tuberculosis bacteria is made of a thick lipid wall. This can easily keep the inner cell intact, protecting it from the action of antibiotics. However, this miraculous chemical breaks down the additional layers of the membrane, and allows the drugs to reach the bacteria and destroy it. Also, the studies showed how the substance inhibited the development of certain enzymes which played a crucial role in the development of the mycomembrane.
This is an important discovery and a huge step for medicine and science. Tuberculosis has always constituted a great medical challenge, and finding out how to combat it represents a huge achievement.
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